Valerio Carelli Selected Research

Leu Transfer RNA

1/2014	A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.
8/2010	High frequency of migraine-only patients negative for the 3243 A>G tRNALeu mtDNA mutation in two MELAS families.

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Valerio Carelli Research Topics

Disease

75	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 02/2022 - 01/2002
41	Mitochondrial Diseases (Mitochondrial Disease) 10/2022 - 05/2002
26	Optic Nerve Diseases (Optic Neuropathy) 01/2021 - 05/2002
19	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2021 - 01/2004
14	Optic Atrophy 01/2022 - 10/2004
11	Neoplasms (Cancer) 01/2022 - 05/2007
8	Osteosarcoma (Osteogenic Sarcoma) 01/2021 - 10/2002
8	MELAS Syndrome (Syndrome, MELAS) 01/2021 - 07/2004
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2011
7	Ganglion Cysts (Ganglion) 01/2022 - 09/2014
7	Mitochondrial Myopathies (Mitochondrial Myopathy) 12/2020 - 02/2008
6	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 01/2022 - 02/2008
5	Stroke (Strokes) 01/2022 - 05/2009
5	Atrophy 01/2021 - 02/2002
5	Hypoxia (Hypoxemia) 01/2021 - 03/2010
4	Leigh Disease (Leigh's Disease) 01/2022 - 02/2002
4	Lactic Acidosis 01/2022 - 05/2009
4	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2022 - 05/2014
4	Ataxia (Dyssynergia) 01/2020 - 02/2008
4	Friedreich Ataxia (Friedreich's Ataxia) 01/2018 - 01/2009
4	Deafness (Deaf Mutism) 07/2015 - 02/2008
3	Migraine Disorders (Migraine) 10/2022 - 08/2010
3	Parkinson Disease (Parkinson's Disease) 01/2022 - 06/2005
3	Neuropathy ataxia and retinitis pigmentosa 12/2021 - 02/2002
3	Parkinsonian Disorders (Parkinsonism) 01/2018 - 07/2015
3	Hearing Loss (Hearing Impairment) 01/2016 - 05/2013
3	Blindness (Hysterical Blindness) 07/2011 - 12/2010
2	Narcolepsy 01/2022 - 06/2014
2	Deglutition Disorders (Dysphagia) 01/2022 - 08/2014
2	Kearns-Sayre Syndrome 12/2021 - 05/2015
2	Brain Diseases (Brain Disorder) 01/2021 - 01/2013
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2021 - 05/2005
2	Fibrosis (Cirrhosis) 01/2021 - 01/2021
2	Wolfram Syndrome (Syndrome, Wolfram) 06/2020 - 01/2020
2	Hereditary Spastic Paraplegia 06/2020 - 05/2009
2	Seizures (Absence Seizure) 01/2020 - 05/2013
2	Cataplexy 01/2020 - 06/2014
2	Myalgia 04/2019 - 05/2013
2	Muscular Diseases (Myopathy) 01/2019 - 08/2014
2	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 01/2016
2	Nervous System Diseases (Neurological Disorders) 01/2018 - 05/2006
2	Breast Neoplasms (Breast Cancer) 01/2017 - 05/2007
2	Peripheral Nervous System Diseases (PNS Diseases) 04/2016 - 07/2015
2	Polyneuropathies (Polyneuropathy) 04/2016 - 02/2008
2	Cardiomyopathies (Cardiomyopathy) 01/2016 - 05/2013
2	Dementia (Dementias) 07/2015 - 01/2015
2	Cognitive Dysfunction 07/2015 - 05/2013
2	Cerebellar Ataxia, Deafness, and Narcolepsy 01/2015 - 05/2014
2	Cataract (Cataracts) 08/2014 - 05/2009
2	Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction) 10/2008 - 03/2006
1	Headache (Headaches) 10/2022
1	Brain Neoplasms (Brain Tumor) 07/2022
1	Papillary Thyroid Cancer 01/2022

Drug/Important Bio-Agent (IBA)

95	Mitochondrial DNA (mtDNA)IBA 02/2022 - 01/2002
29	Retinaldehyde (Retinal)IBA 01/2022 - 01/2005
10	Proteins (Proteins, Gene)FDA Link 12/2021 - 08/2006
7	DNA (Deoxyribonucleic Acid)IBA 07/2022 - 06/2006
7	idebenoneIBA 01/2021 - 09/2011
7	Adenosine Triphosphate (ATP)IBA 05/2011 - 02/2002
6	Lactic Acid (Lactate)FDA LinkGeneric 10/2022 - 08/2010
6	melanopsinIBA 01/2022 - 08/2010
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2013
5	AntioxidantsIBA 01/2021 - 03/2005
5	Glutamic Acid (Glutamate)FDA Link 01/2020 - 10/2004
5	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2017 - 03/2010
5	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2011 - 01/2004
4	Pharmaceutical PreparationsIBA 01/2021 - 12/2016
3	RotenoneIBA 02/2022 - 08/2006
3	Amino Acids FDA Link 05/2018 - 11/2004
3	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 02/2003
3	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2015 - 01/2011
2	AcidsIBA 10/2022 - 01/2021
2	OrexinsIBA 01/2022 - 06/2014
2	NADH DehydrogenaseIBA 01/2022 - 11/2004
2	salicylhydroxamic acid (SHAM)IBA 01/2021 - 12/2020
2	Thymidine PhosphorylaseIBA 01/2021 - 10/2008
2	EnzymesIBA 01/2021 - 03/2013
2	Alanine (L-Alanine)FDA Link 01/2021 - 05/2018
2	fibroblast growth factor 21IBA 12/2020 - 10/2020
2	Creatine Kinase (Creatine Phosphokinase)IBA 12/2020 - 05/2013
2	CalciumIBA 06/2020 - 01/2020
2	MethyltransferasesIBA 01/2020 - 01/2020
2	Protons (Proton)IBA 01/2017 - 05/2006
2	FrataxinIBA 01/2017 - 01/2009
2	Estrogens (Estrogen)FDA Link 12/2015 - 03/2014
2	NucleotidesIBA 08/2014 - 06/2002
2	MelatoninIBA 06/2014 - 08/2010
2	Leu Transfer RNAIBA 01/2014 - 08/2010
2	Phosphorus (Red Phosphorus)IBA 05/2011 - 01/2011
2	Galactose (Galactopyranose)FDA LinkGeneric 01/2011 - 02/2003
2	GTP Phosphohydrolases (GTPases)IBA 02/2008 - 11/2004
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 02/2008 - 07/2004
2	Dynamins (Dynamin)IBA 02/2008 - 11/2004
2	VitaminsIBA 01/2004 - 05/2002
1	Analgesics (Analgesic Drugs)IBA 10/2022
1	quinone (benzoquinone)IBA 02/2022
1	HDL CholesterolIBA 01/2022

Therapy/Procedure

11	Therapeutics 10/2021 - 02/2011
3	Lasers (Laser) 01/2022 - 02/2014
2	Intravitreal Injections 01/2021 - 12/2020